Testosterone decanoate and nandrolone decanoate difference
Fred R. Sattler, S. Victoria Jaque, E. This nonplacebo-controlled, open label, randomized study was conducted to test the hypotheses that pharmacological doses of nandrolone decanoate would increase lean body tissue, muscle mass, and strength in immunodeficient human immunodeficiency virus-infected men, and that these effects would be enhanced with progressive resistance training PRT.VIDEO ON THE TOPIC: Deca Durabolin - Must-Know Benefits & Side Effects
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Nandrolone decanoate/testosterone enanthate/testosterone propionate abuse
Background: Anabolic-androgenic steroids AAS are abused by athletes. Objectives: The present study was designed to evaluate chronic administration of high doses of nandrolone decanoate ND on the pituitary-gonadal axis and hematological parameters in normal male rats. Group P received the same volume of peanut oil, but group C did not receive any agent during the trial period.
At the end, animals were anesthetized, killed and blood samples collected from cervical vessels. Serum testosterone and hematological parameters were measured by ordinary laboratory methods.
Testosterone Rats Nandrolone Decanoate. Nandrolone decanoate ND is an anabolic-androgenic steroid AAS used by athletes to improve their athletic ability and muscle mass 1.
Anabolic-androgen steroids had various benefits for patients with anemia 2. Administration of ND for six months could increase hemoglobin and hematocrit in anemic men 3. Chronic AAS administration may alter the melanocortin system activity and appetite and food intake in rats 4. Studies showed that chronic administration of ND induces deep changes to mental health in rats 5 and causes DNA damage in leukocytes, liver, bone marrow, brain and testicle cells in mice 6.
Sex steroid hormones can have a direct performance on the pituitary, follicle stimulating hormone FSH and luteinizing hormone LH secretion 7. Androgenized female rats showed alteration in the morphometric thickness of the luminal epithelium, myometrium and perimetrium associated with infertility when treated with steroids in the pre-gestational period 8.
Since ND is abused by athletes and youth, the aim of the present study was to evaluate the effect of high doses of ND administration on serum FSH, LH, weight gain, food and water intake and hematological parameters in male rats.
Animals: This experiment was performed on 30 Wistar-Albino male rats, weighing grams kept in Zahedan University of Medical Sciences animal house and distinctly housed in cages.
The present study received institutional ethical approval from the animal research committee of Zahedan University of Medical Sciences issued Group C did not receive any agents in experimental period.
ND Iran Hormone L. C was purchased from a city drugstore and sustained in the appropriate temperature. At the end of trial period, animals were weighted final weight and deeply anesthetized by diethyl ether Merck Germany , killed and blood samples were collected from cervical vessels.
Residual blood samples were collected in ordinary vials and centrifuged at rpm for 10 minutes to separate serum. Serum testosterone was measured by standard laboratory Mino bine human kit USA methods. Hematological parameters measured by usual laboratory methods. In addition, erythrocytes; hemoglobin, hematocrit, Leukocyte and platelets values were increased in group T.
High doses of AAS used for athletic enhancement can lead to irreversible organ damage such as reduced fertility and gynecomastia in males 9.
Moreover, AAS has a high affinity for the androgen receptor in central and peripheral tissues and causes impairments in hypothalamicpituitary-gonadal axis 9. In addition, Kuhn CM reported that AAS affects androgen receptors and alters enzymatic aromatization of testosterone derivatives to increase its affinity to estrogen receptors These results are the same as Alsio 11 , which reported that AAS administration was probable to reduce hypothalamic-pituitary-gonadal axis activity by affecting physiological feedback mechanisms.
Bijlsma et al. Our findings showed that FSH value in group T was significantly deceased compared to that of other groups and it was the same as literature study Oda and El-Ashmawy 12 reported that chronic administration of ND caused decrease in testes and epididymis weights, but did not show any significant changes in weight gain in normal rabbits.
Our results are different with that of Oda and El-Ashmawy This difference is probably due to different used animals. Our findings were in accordance with the theory that sex steroids hormones can act directly on the hypothalamus- pituitary-testis axis and resulting in selective FSH and LH secretion 8. In addition, our outcome was in agreement with that of Shokri et al. Our study revealed that weight gain, food and water intake in group T were significantly decreased compared to those of other groups, which is in accordance with the literature Bhasin et al.
In the present study, erythrocyte, hemoglobin, hematocrit, leukocyte and platelets values in group T were significantly increased compared to those of other groups and confirmed by another investigation This is presumably because chronic ND administration in the present study increased metabolism, serum erythropoietin concentration and stimulated hematopoiesis in bone marrow.
In conclusion, chronic administration of high doses of ND administration could alter serum FSH, LH, testosterone, weight gain, food and water intake and hematological parameters in male rats. Detection of nandrolone, testosterone, and their esters in rat and human hair samples. J Anal Toxicol. Nandrolone decanoate for the treatment of erythropoietin refractory anemia: a case series.
Compr Ther. Nandrolone decanoate is a good alternative for the treatment of anemia in elderly male patients on hemodialysis. Geriatr Nephrol Urol. Anabolic androgenic steroid nandrolone decanoate reduces hypothalamic proopiomelanocortin mRNA levels.
Brain Res. Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. Nandrolone androgenic hormone presents genotoxic effects in different cells of mice. J Appl Toxicol. Influence of nandrolondecanoate on the pituitary-gonadal axis in males. Acta Endocrinol Copenh. Rev Bras Ginecol Obstet. Adverse effects of anabolic steroids in athletes.
A constant threat. Toxicol Lett. Kuhn CM. Anabolic steroids. Recent Prog Horm Res. Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroids. Basic Clin Pharmacol Toxicol. Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits.
Int J Exp Pathol. Exercise and supraphysiological dose of nandrolone decanoate increase apoptosis in spermatogenic cells. Effect of testosterone supplementation with and without a dual 5alpha-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. Published Online: September 15, Article Type: Brief Report.
Received: October 13, Revised: February 16, Accepted: May 6, DOI : This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.
Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness
Nandrolone first began to be used in , as Nandrolone Phenylpropionate, which is an ester variant of Nandrolone and its effects are felt very quickly. The anabolic steroid Nandrolone is sold and traded under the brand name, Deca Durabolin. To be clearer, Deca Durabolin is the Decanoate ester variant of nandrolone and its commercial name is Deca Durabolin.
Male hypogonadism is a clinical entity characterized by symptoms such as fatigue, erectile dysfunction ED and mood changes associated with decreased serum levels of testosterone 1. Treatment of hypogonadism involves the exogenous supplementation of testosterone and may be complemented with other medications such as human chorionic gonadotropin hCG and clomiphene citrate clomid 2 - 4. The fact that these anabolic steroid medications are banned by numerous athletic associations such as the International Olympic Committee as well as the National Football and Basketball Associations and Major League Baseball, further re-enforces the public perception that these medications should not be used under any circumstances. Indeed, a recent study 5 evaluated healthcare-provider attitudes towards anabolic androgenic steroids AAS and found that AAS users were viewed less favorably that cocaine abusers or healthy adults. These perceptions were enhanced by the passage of the Anabolic Steroid Control Act of that listed anabolic steroids as schedule III controlled substances—similar to ketamine, opiates and morphine 6.
Background: Anabolic-androgenic steroids AAS are abused by athletes. Objectives: The present study was designed to evaluate chronic administration of high doses of nandrolone decanoate ND on the pituitary-gonadal axis and hematological parameters in normal male rats. Group P received the same volume of peanut oil, but group C did not receive any agent during the trial period. At the end, animals were anesthetized, killed and blood samples collected from cervical vessels. Serum testosterone and hematological parameters were measured by ordinary laboratory methods. Testosterone Rats Nandrolone Decanoate. Nandrolone decanoate ND is an anabolic-androgenic steroid AAS used by athletes to improve their athletic ability and muscle mass 1. Anabolic-androgen steroids had various benefits for patients with anemia 2.
Anabolic steroids are known to increase muscle mass and strength in healthy individuals, but their effect on the sarcopenia and fatigue associated with long-term dialysis has not been evaluated. Time to complete the walking and stair-climbing test decreased from Peak oxygen consumption increased in the individuals in the nandrolone group who performed treadmill tests, but not to a statistically significant degree. Grip strength did not change in either group. In the United States, the average life span of a patient entering a long-term dialysis program is less than half that of an age-matched control not receiving dialysis.
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Every Amateur secretly dreams of becoming a professional in a particular sport with an exceptional body, comparable to the bodies of the ancient Greek mythical gods. But getting the best result can take away a huge amount of valuable time from an ordinary person with average physique. And these are not just words, but reliable and verified facts by highly qualified specialists. The progressive world does not stand still, but only moves forward in huge leaps.
The impact of exogenic testosterone T : 1. Results revealed that T and ND significantly increased the weight of androgen target tissues as follows: ND was more influential on seminal vesicles, levator ani-bulbocavernosus muscle LABC and Cowper's glands and T at a dose of 3. The results of this research proved the disrupting activity of T and ND when administered in high doses and the useful application of the Hershberger bioassay in the case of ND. This is an open-access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. We confirm that all data underlying the findings in this study are freely available in the manuscript and its supplemental files.
Testosterone decanoate BAN is an androgen and anabolic steroid and a testosterone ester. From Wikipedia, the free encyclopedia. Interactive image. Elks 14 November January
Nandrolone decanoate , sold under the brand name Deca-Durabolin among others, is an androgen and anabolic steroid AAS medication which is used primarily in the treatment of anemias and wasting syndromes , as well as osteoporosis in menopausal women. Side effects of nandrolone decanoate may include symptoms of masculinization like acne , increased hair growth , voice changes , and increased sexual desire. Nandrolone decanoate was first described in and was introduced for medical use in
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