Ecdysterone and testosterone levels
Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor ER binding. Within this study the anabolic potency of ecdysterone was compared to well characterized anabolic substances. Effects on the fiber sizes of the soleus muscle in rats as well the diameter of C2C12 derived myotubes were used as biological readouts. Ecdysteroids are widely marketed to athletes as dietary supplement, advertising to increase strength and muscle mass during resistance training, to reduce fatigue and to ease recovery. Several studies have reported a wide range of pharmacological effects of ecdysteroids in mammals, most of them beneficial to the organism. Extensive investigations on the possible growth-promoting effects of ecdysterone in various animal species rats, mice, Japanese quail and cattle and in humans [ 1 — 13 ] were reported and lots of rumors on its misuse by athletes are circulating since then.VIDEO ON THE TOPIC: Popeye was right: Scientist of FU Berlin detected a performance-enhancing substance in spinach
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Ecdysteroids: A novel class of anabolic agents?
One category of dietary supplements that continues to experience controversy is the so-called prohormones or testosterone precursors. For purported muscle building enhancement these products typically contain DHEA dehydroepiandrosterone and Andro androstenedione.
They are also the precursors of testosterone and estrogens. In general there are two groups of males who are interested in increasing their testosterone levels, young athletic adults and older adults. This interest in increasing testosterone levels is based on the fact that testosterone is the primary male hormone responsible for building and maintaining big muscles and masculinizing effects.
Among females, testosterone is found in much lower levels, but also exerts anabolic and masculinizing effects if the levels are artificially increased. A review of the medical research will be helpful in leading to an objective viewpoint on the usefulness of these prohormone-testosterone boosting supplements for sports nutrition applications, sorting gym hype from scientific evidence.
DHEA is a steroid hormone produced mainly by the adrenal glands. In men, it is also produced in the testes as an intermediate in testosterone production, and in women, it is also produced in the ovaries as an intermediate in estrogen production. DHEA is weak androgen a steroid hormone that promotes masculine characteristics , and it has been reported to induce growth of body hair in men and women.
In a pilot study using men between the ages of twenty and twenty-five, supplemental DHEA did not increase testosterone levels but did appear to help decrease body fat and increase lean body mass. However, when this study was duplicated, no significant changes in body composition were observed. Conversely, in another study, an increase in androgen levels was reported in postmenopausal women given supplemental DHEA, as was an increase in body-hair growth during the study period.
Another study, this one using both men and women, did not report any significant changes in lean body mass or body fat but did report an overall improvement in the feeling of well-being. This last study also reported a possible anabolic effect-an increase in the IGF-I level. IGF-I is an important growth promoter in muscles, especially in individuals undergoing intensive training.
Major studies with athletes taking DHEA supplements have not yet been reported. However, a small study with young weight lifting men average age 23 years old , taking 50 mg of DHEA per day, did not report any improvements in strength and lean body mass when compared to the placebo group. However, careful use by female athletes and male athletes over age forty may cause some beneficial physical and physiological effects.
Other reported benefits of DHEA include immune-system enhancement, antidepressant action, enhancement of mental functioning, and longevity in laboratory animals. The amounts used in studies have varied, but benefits have been reported in the 25 to milligram per day range, with 50 milligrams per day being reported safe for short-term use of several months.
A word of caution: do not take supplemental DHEA if you are a man who may have prostate cancer or a woman who may have breast cancer, a reproductive cancer, or a reproductive disorder, and only use under doctor supervision. Androstenedione has an equally dubious origin as it applies to sports nutrition. You will commonly encounter reference to a study conducted by V. Mahesh and R. Greenblatt used by Andro supplement companies to substantiate that Andro supplements are effective at boosting testosterone levels and promoting larger muscles and strength.
You may be surprised to learn that the Mahesh study used only 4 nonathletic women. Furthermore the results of the study were based on one dose of either mg of DHEA taken by two of the women or mg of androstenedione taken by the other two women, lasting only several hours. You will commonly encounter this scientific reference used in promotional literature as substantiation of Andro supplements Mahesh, V.
You now know that the study substantiates nothing as far as sports nutrition is concerned. Some Andro studies later conducted using males did not show a significant rise in testosterone levels or significant improvements in muscle size or strength. While millions of andro tablets are consumed per day by iron pumping athletes, recent research adds to the disappointing news of previous studies. For example, a recent study looked at the effects of an androstenedione complex formula had on weight lifting males.
The complex formula contained a daily dosage of mg of androstenedione, plus, mg of DHEA, mg of Tribulus terrestris, mg of chrysin, mg of indolecarbinol, and mg of Saw palmetto.
Blood levels of androstenedione concentrations did increase in the supplement taking group when compared to the placebo group. During the 8 week study period, muscle strength was increased in both the groups, but the differences were not significant.
The researchers also observed the use of the androstenedione complex formula did not result in increased serum testosterone concentrations. The increased production of estrogen caused by the androstenedione supplement was not reduced by the addition of chrysin. All told, the andro supplement did not cause additional benefits to resistance-training young adults. One group of researchers, lead by Gregory Brown, recently reported in the Journal of Applied Physiology that the effectiveness of orally ingested androstenediol in raising serum testosterone concentrations might be limited because of liver breakdown.
Brown and coworkers conducted a study where men experienced in strength training ingested 20 mg androstenediol in a sublingual tablet, or a placebo. The sublingual androstenediol tablets did cause a significant increase in these young men average age The practical benefits of the results of this study need to be determined in future studies.
On the practical side, as these supplements act as hormones in the body, it is reasonable to use only under doctor supervision just in case an adverse hormonal imbalance or other adverse event occurs.
The medical community notes that until more studies are performed using these supplements, safety should not be assumed, and side effects too numerous to list here common to anabolic-androgenic steroids and estrogens, might be expected when using these testosterone precursor prohormones. Concerning the issue of potency, the best way to confirm this is by requesting an independent laboratory analysis from the manufacturer. In fact, the most recent research confirms that the simple act of living a healthy lifestyle, consisting of regular exercise and good nutrition, is the best way to maximize testosterone levels.
While it is well known that strength training increases testosterone levels, a recent study reported that in middle aged men, being in good health was associated with highest testosterone levels. Good health was defined as the absence of chronic illness, prescription medication, obesity, or excessive drinking of alcoholic beverages.
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Supplements For Boosting Testosterone Levels, Yea or Nay.
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One category of dietary supplements that continues to experience controversy is the so-called prohormones or testosterone precursors. For purported muscle building enhancement these products typically contain DHEA dehydroepiandrosterone and Andro androstenedione. They are also the precursors of testosterone and estrogens. In general there are two groups of males who are interested in increasing their testosterone levels, young athletic adults and older adults.
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Methoxyisoflavone M , hydroxyecdysone E , and sulfo-polysaccharide CSP3 have been marketed to athletes as dietary supplements that can increase strength and muscle mass during resistance-training. However, little is known about their potential ergogenic value. Forty-five resistance-trained males At 0, 4, and 8-weeks, subjects donated fasting blood samples and completed comprehensive muscular strength, muscular endurance, anaerobic capacity, and body composition analysis. Over the last few years, methoxyisoflavone, ecdysterones, and sulfo-polysaccharide a purported myostatin inhibitor have been marketed as potential anabolic promoting nutritional supplements for resistance-trained athletes. Unfortunately, little well-controlled research has been conducted to examine the potential ergogenic properties of these nutrients. Methoxyisoflavone is a member of the flavonoids isoflavones family that are primarily obtained in the diet from soybeans and soy foods [ 1 ]. The two most popular forms of methoxyisoflavones on the market are 5-methylmethoxy-isoflavone Methoxyiso-flavone and 7-Isopropoxyisoflavone Ipriflavone. Initial claims based on animal research suggested that methoxyisoflavone supplementation possesses a muscle-building and bone-building anabolic component without the side effects of traditional hormone replacement therapies that would give similar results [ 1 ]. Despite these claims, the only beneficial effect of methoxyisoflavone that has been reported in multiple research publications and U.
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Сьюзан собралась с мыслями и шагнула в дверной проем. Компьютер зафиксировал ее прибытие. Хотя Сьюзан практически не покидала шифровалку в последние три года, она не переставала восхищаться этим сооружением.
First-hand experience with Ecdysterone
Это лето было такое ужасное, - говорила она, чуть не плача. - Я вам так признательна. Я так хочу выбраться отсюда. Беккер легонько обнял .
Честно говоря, - нахмурился Стратмор, - я вообще не собирался этого делать. Мне не хотелось никого в это впутывать. Я сам попытался отправить твой маячок, но ты использовала для него один из новейших гибридных языков, и мне не удалось привести его в действие. Он посылал какую-то тарабарщину. В конце концов пришлось смирить гордыню и вызвать тебя. Сьюзан это позабавило.
Ecdysterone (95% Beta Ecdysterone) 90 Capsules
- Беккер улыбнулся и над столом протянул парню руку. Панк брезгливо ее пожал. - Проваливал бы ты, пидор. Беккер убрал руку. Парень хмыкнул. - Я тебе помогу, если заплатишь. - Сколько? - быстро спросил Беккер.
Беккер попридержал его еще минутку, потом отпустил. Затем, не сводя с него глаз, нагнулся, поднял бутылки и поставил их на стол. - Ну, доволен. Тот потерял дар речи.
Парень расплылся в широкой улыбке. - А то ты не знаешь. Беккер пожал плечами.
Командир подводной лодки мог получить последние спутниковые фотографии российских портов, но не имел доступа к планам действий подразделений по борьбе с распространением наркотиков в Южной Америке. Эксперты ЦРУ могли ознакомиться со всеми данными об известных убийцах, но не с кодами запуска ракет с ядерным оружием, которые оставались доступны лишь для президента. Сотрудники лаборатории систем безопасности, разумеется, не имели доступа к информации, содержащейся в этой базе данных, но они несли ответственность за ее безопасность.
Но того человека в очках нигде не. Были другие люди.
Если вы назовете мне его имя, я сделаю все, чтобы он получил свой паспорт немедленно. - Да что вы… Мне кажется, что… - Зашелестели перелистываемые страницы. - Имя немецкое. Не знаю, как оно правильно произносится… Густа… Густафсон.
Куда она могла уйти. Неужели уехала без меня в Стоун-Мэнор. - Эй! - услышал он за спиной сердитый женский голос и чуть не подпрыгнул от неожиданности.
- Я… я… прошу прощения, - заикаясь, сказал Беккер и застегнул молнию на брюках. Повернувшись, он увидел вошедшую в туалет девушку. Молоденькая, изысканной внешности, ну прямо сошла со страниц журнала Севентин.
Самый крупный мужчина из всех, с кем ей приходилось иметь. Нарочито медленно она взяла из ведерка кубик льда и начала тереть им соски. Они сразу же затвердели.