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Can a woman use bone marrow to get pregnant

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Bone marrow may be the missing piece of the fertility puzzle

The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy.

But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

Reshef Tal , first author of the study and assistant professor of obstetrics, gynecology and reproductive sciences at Yale. In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium.

In mice with only one copy of the defective gene, the transplant saved pregnancies that would otherwise have been lost and increased litter sizes, while in the mice with two bad copies of the gene, which were thus entirely infertile, the transplant caused growth and repair of the defective endometria.

This study was made possible by a methods breakthrough that Tal and Taylor made a few years ago. Before a bone marrow transplant, chemotherapy or radiation is used to clear the body of the existing bone marrow, so that the donor bone marrow can take its place. Though more research is needed prior to clinical trials, Tal and Taylor see hope for the patients they treat for infertility on the clinical side of their practice in this latest advance. Bone marrow can be considered another critical reproductive organ.

This finding opens up a new potential avenue for treatment of a condition that has been untreatable in the past. Leet and Clara Guthrie Patterson Fellowship. Kendall Teare: kendall. Bone marrow may be the missing piece of the fertility puzzle By Kendall Teare. Media Contact Kendall Teare: kendall.

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Bone marrow stem cells may be vital for pregnancy

Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner. It is therefore concluded that most of the W-bearing PGC could not differentiate into spermatozoa because of restricted spermatogenesis.

Stem cells have generated such an enormous amount of interest, in part, because of their applications related to areas such as fertility and genetics. In that same light, their interest for solving reproductive challenges has also generated a great deal of controversy.

Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published September 12 in the open-access journal PLOS Biology. Although the study was done in mice, it raises the possibility that dysfunction of bone marrow-derived progenitor cells may contribute to implantation failure and pregnancy loss in women. Bone marrow progenitors can become either blood or tissue cells. Within the uterus they differentiate into endometrial tissue cells in the lining of the womb, but until now it was not known if they have a function in pregnancy. Reshef Tal and colleagues from Yale School of Medicine developed a bone marrow transplantation protocol that preserved ovary and reproductive function, allowing them for the first time to track these cells in pregnancy, showing that during pregnancy cells from the bone marrow were preferentially recruited to the uterus and were concentrated near the site of implantation, on the maternal side of the placenta.

Will science render men unnecessary?

The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy. Reshef Tal , first author of the study and assistant professor of obstetrics, gynecology and reproductive sciences at Yale. In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium. In mice with only one copy of the defective gene, the transplant saved pregnancies that would otherwise have been lost and increased litter sizes, while in the mice with two bad copies of the gene, which were thus entirely infertile, the transplant caused growth and repair of the defective endometria. This study was made possible by a methods breakthrough that Tal and Taylor made a few years ago. Before a bone marrow transplant, chemotherapy or radiation is used to clear the body of the existing bone marrow, so that the donor bone marrow can take its place.

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But recently a team of scientists announced they had made artificial sperm from human bone marrow , and media reports abounded with the dire news that my goodfellas and by extension, me had been rendered unnecessary. There are at least half a dozen reasons why such speculation is silly, some scientific and some practical. For example, as long as sex feels good and remains no more expensive than dinner and a bottle of wine, most people will use natural-grown sperm. Still, suggests Gregory Stock, director of the program on medicine, society and technology at the UCLA School of Medicine and the CEO of a biotech company called Signum Biosciences, it is very interesting that there were any stories at all.

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Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift.

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By Roxanne Khamsi. In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm. But experts caution that provoking the sperm precursors to fully mature presents a serious challenge.

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Stem Cells and Same Sex Reproduction

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Sep 12, - Bone marrow progenitors can become either blood or tissue cells. showing that during pregnancy cells from the bone marrow were preferentially The authors then made use of mice that lack Hoxa11, a protein which is found in as well as developing new treatments for women suffering from them.".

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Cells that make bone marrow also travel to the womb to help pregnancy

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